JUVENILE RENAL DYSPLASIA (JRD)
"UPDATES"
EVERY GSD IS A "POTENTIAL JRD CARRIER" UNLESS TESTED "JRD CLEAR"

It is well to remember the lines of the philosopher Hippocrates in 360 BC, when he said “There are in fact two things:- science and opinion. The former begets knowledge, the latter ignorance.” Evidence-based science is, where possible, on what judgements should be made.

Readers will note from the pedigrees below of "JRD carriers, that Sieger Uran vom Wildsteiger Land is a common ancestor. Int. Ch. Rosehurst Chris is also implicated.
 

WORLD INTELLECTUAL PROPERTY ORGANIZATION
Pub. No.:  WO/2009/092171  
READ HERE

The JRD CARRIERS already identified clearly indicate the following GSD should be JRD DNA tested - Corjon Mark, his mother Bygoly Miss Moneypenny at Corjon, her litter brothers & sisters, and ALL offspring from Corjon Mark, including the Aufraumen 'C' litter. The Corjon 'P' litter (repeat mating of the Corjon Mark 'M' litter).

IMPORTANT NOTE
I am informed by the owners of Corjon Mark that he was withdrawn from stud earlier this year - his last stud was November 2007 to Nikonis Bria - this mating produced the Nikonis 'A' litter, referred to below.
                                 ----------------------------------------------------------
The sire & dam of Bygoly Miss Moneypenny at Corjon is Esko vom Danischen Hof & Wereunas Breeze if both or either of these GSD appear in your GSD's pedigree it may be useful to test them. If Bygoly Miss Moneypenny is found to be a carrier, this would point to the need to test the rest of her siblings (9) and the repeat mating (8) - and their offspring. From this you can see the value to our breed of publishing the "JRD CARRIERS"

Note: There are other kidney diseases and reasons for kidney (renal) failure in dogs. Hopefully a DNA test will be found for some of the other kidney hereditary diseases.

Please read these articles - they can be read in various languages if the Google language is first selected above.

Canine Renal Disease

Canine Genetic Disorders - Canine Genetic Diseases Affecting The German Shepherd Dog   (not just white GSD)
look for the following information in this article:

Mode of
Inheritance  < Age at Onset * Name of Disease

Kidney Failure in the Dog
 

Canine Kidney Disease

Canine Kidney Health

NIKONIS 'A' LITTER

7 PUPPIES TESTED
3 CARRIERS + 3 HOMOZYGOTE CARRIERS (THIS MEANS BOTH PARENTS MUST BE CARRIERS)+ 1 CLEAR

LITTER PEDIGREE

Sire: CORJON MARK (NOT TESTED)            X         Dam: NIKONIS BRIA (CARRIER)

Sire: CH. Philipp (CLEAR)
Dam: Bygoly Miss Moneypenny at Corjon (NOT TESTED)                                               

     Sire: Yak vom Frankengold (NOT TESTED)
     Dam: Nikonis Rena (CARRIER)
                            

PEDIGREE OF "NIKONIS RENA" (CARRIER)

BREEDERS SHOULD CONSIDER "JRD DNA TESTING" GSD CONTAINING THESE BLOODLINES
PARTICULARLY THE SIRE & DAM

"NIKONIS GSD" - JRD DNA TEST RESULTS - RECEIVED 26/06/2008

THE FOLLOWING GSD (IN BOLD LETTERS) HAVE BEEN JRD DNA TESTED "CLEAR"

Nikonis Ghost "CLEAR"-   (Sire: Sailent vom Portaner x Dam: Nikonis Rena)
Nikonis Kimon "CLEAR"-  (Sire: Rocky vom Haus Tepford x Dam: Nikonis Rena)
Jupaala Francisco "CLEAR"–  (Sire: Ch Nikonis Yago x Dam: Jupaala Ute)
Neerlaws Neeko "CLEAR"–  (Sire: Ch Nikonis Colin x Dam: Mercedes Morgan via Neerlaws)
Nikonis Shana "CLEAR"–  (Sire: Arko vom Butjenter Land x Dam: Nikonis Rena)
Nikonis Betti "CLEAR"–  (Sire: Yak vom Frankengold x Dam: Nikonis Rena)
Ch Nikonis Colin "CLEAR"–  (Sire: Whisky vom Bierstadter Hof x Dam: Ch Nikonis Elektra)
Gayville’s Winnona "CLEAR"–  (Sire: Ch Nikonis Colin x Dam: Ch Gayville’s Italia)
Sailent vom Portaner "CLEAR"–  (Sire: Timo vom Berrekasten x Dam: Hella vom Portaner)
Graychelsea’s Hannah vom Nikonis "CLEAR"–  (Sire: Ch Nikonis Colin x Dam: Nikonis Xahna)
Ch Nikonis Yago "CLEAR"–  (Sire: Timo vom Berrekasten x Dam: Ch Nikonis Elektra)
Nikonis Karri "CLEAR"-   (Sire: Rocky vom Haus Tepford x Dam: Nikonis Rena)
Nikonis Viva "CLEAR"–  (Sire: Jascho vom Fiemereck x Dam: Nikonis Xena)
NEW Nikonis Nancy "CLEAR"– (Sire: Basko vom Deininghauser Park x Dam: Nikonis Rena)
NEW Nikonis Varus "CLEAR"-  (Sire: Phillip aus der Neuen Hauffstrasse x Dam: Nikonis Bria)
NEW Nikonis Vectra "CARRIER"– (Sire: Phillip aus der Neuen Hauffstrasse x Dam: Nikonis Bria) 
         You will note from the above information that CARRIERS can produce CLEARS
So please understand that one CLEAR in a litter does NOT mean that ALL the litter is CLEAR or that its parents are CLEAR
          ONLY WHEN BOTH PARENTS ARE CLEAR WILL THE WHOLE LITTER BE CLEAR

PEDIGREE OF "BYGOLY MISS MONEYPENNY AT CORJON"
NEW THIS FEMALE HAD MANY LITTER BROTHERS & SISTERS WHICH INCLUDES: BYGOLY EL DEVINO
THERE WAS ALSO A REPEAT LITTER FROM THIS SAME BREEDING
I WOULD ADVISE TESTING ALL OFFSPRING FROM THESE LINES

BREEDERS SHOULD SERIOUSLY CONSIDER "JRD DNA TESTING" GSD CONTAINING THESE BLOODLINES

What does this JRD DNA test actually tell the breeder?

The DNA test results are reported as follows:

a) Carrier (one copy of the JRD mutation)

b) Homozygous mutant allele = Homozygote Carrier (two copies of the JRD mutation)

c) Clear.

With a & b results above – the dog is also potentially affected by JRD.

This DNA test information is clearly important for breeders, and important for the future of the breed. Carriers of this mutation bred to a clear, approximately 50% of the offspring will be clear of the mutation. Individuals with two copies of the gene homozygote carriers bred to a clear will produce all carriers.

Note: all genes are in pairs - 1 from the mother & 1 from the father
In a homozygote carrier both are mutated (JRD) this clearly indicates that a homozygote carrier received 1 from its mother & 1 from its father - you will now hopefully understand why Corjon Mark will be a JRD carrier. You will also note that the Father of Corjon Mark, CH. Phillip is CLEAR, so therefore Corjon Mark  must of obtained his JRD mutation gene from his mother, Bygoly Miss Moneypenny at Corjon.
 

TAKE CARE - IF YOU WANT TO AVOID BUYING A PUPPY WITH JRD

OBTAIN YOUR JRD DNA TEST KITS
FROM

Dogenes Inc

THIS IS PLACED HERE BECAUSE I RECEIVE NUMEROUS REQUESTS FOR THIS INFORMATION
I HAVE NO COMMERCIAL ARRANGEMENTS WITH DOGENES INC.